EGAA 5 – Malaria

Contents:

sesame oil 61,6 %
silicon dioxide 38,0 %
plant extracts 0,4 %
Composed of 64 % Hydrastis Canadensis
22 % Ocimum sanctum kilemandscharikumX Basilicum purpurescens
11 % Caesalpina bonduc (Cassane, Norcassane)
3 % Piper nigrum

Boost effect by quantum point technology:
1:1,6 for cassanes

Case study (Gradl Rohr 2012)

22 malaria patients in Tanzania (infection with Plasmodium malariae, malaria quartana) received 3 capsules (200 mg EGAA-5) a day for 5 days. After 3-5 days parasites had been determined in blood.

In 14 patients after 3 days and in 8 patients after 5 days no parasites could be found.

Mechanism of action

EGAA-5 is a combination of two medical plants (Ocimum kilimandscharicum X Basilicum purpurescens; Caesalpina bonduc) with known activities against plasmodium species, and with golden seal (Hydrastis canadensis) that partly works on the cellular immune system and inhibits (mainly by berberine species) the efflux pump that causes a multi-drug resistance. A pepper extract (piper nigrum) acts as a bioactivity enhancer.

The single plant extracts are prepared as quantum dots (Gradl 2008; Gradl 2011) making very small quantities of the extracts possible.

One of the problems of malaria treatment is that plasmodium quickly can become resistant to drugs. By a membrane pump the reflux quickly enhances (Quellette, Légaré, Papadopolou 2001). This resistance shares many phenotypic features with multidrug resistance of mammalian tumour cell lines (Martin et al. 1987). By using Verpamil it was possible to restore partially sensitivity to anti-malaria drugs.

Golden seal being well known as an anti-malaria herb contains isoquinoline alcaloids like hydrastine, berberine, berberstine, hydrastinine, tetrahydroberberastine, canadine and canalidine. Golden seal can inhibit by some or all of them the cellular pump being responsible for resistances.

Ocimum species contain eugenol (1-hydroxy-2-methoxy-4-allylbenzene) being responsible for its action against plasmodium (Prakash, Gupta 2005).
Caesalpina species contain diterpenes of cassane and norcassane types with activity against plasmodium (Linn et al. 2005).

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