|Silicon dioxide||47,8 %|
|Incense (resin of Boswellia carterii)||32,2 %|
|Line seed oil
containing 11,3 % Omega-3 fatty acid
from it 5.4 % alpha linoleic acid
|Curcumin (extract from Curcuma longa)||0,5 %|
Boosting by quantum point technology:
1:100 for curcumin
1:9 for incense
To 19 people suffering from rheumatic diseases 3 tablets EGAA-1 (450 mg each) were administered daily between 2 and 6 weeks. In 14 cases the symptoms became better, in 2 cases there was no further control. Only in two cases the disease became worse.
Mechanism of action
For RA several pathogeneses are discussed. Mostly accepted is the assumption or significant participation of an immune pathogenesis. T-lymphocytes activate synovial macrophages, secreting inflammatory cytokines TNF-α and IL-1, causing by that way osteoclasts and chrondrocytes to destroy cartilage and bone in a pincer movement. In a vicious circle chondrocytes produce big quantities of FGF and GM-CSF who again stimulate macrophages. The control is performed via the HPA-Axis (Turnbull, Rivier 1999) where IL-1 and TNF-α stimulates the formation of CRH in the hypothalamus. CRH causes in the pituitary gland the formation of ACTH, which causes the adrenal cortex to produce corticosteroids.
There are two possibilities. In one case the pituitary gland reacts to CRH and AVP excretion of the hypothalamus by promoting the inflammatory reaction by prolactin and MIF. In the other case the adrenal cortex is caused by ACTH to produce cortisol and DHEAS (Cutolo, 2002). In this way a positive feed-back reaction can be avoided in which IL-6, IL-1 and TNF-α from the inflammation stimulates the hypothalamus. This mechanism seems to play an important role in rheumatic diseases. Instead of using corticosteroids for RA-therapy for some years blockers of TNF-α (Anakinra; Kineret) are used. It is supposed that by using cytokine-blockers less side effects can occur than by using corticosteroids. On the other hand blocked cytokines also play an important role in other parts of the body beside of RA-inflammation. Susceptibility to infections is higher during this therapy. Research of Aggarwal (1999) und Mukhopadhyay et al. (2001) showed that natural substances like curcumin (from curcuma roots) can inhibit the formation of cytokines. The mechanism is an inhibition of the activation of NFκB-transkriptionsfactor. The phytotherapeutic use of other pungent flavours in RA-therapy like gingerol from ginger or eugenol from cloves may be based on the same effect.
Pungent flavours used orally in higher concentrations or for a longer period can cause unpleasant side-effects Therefor they are used as quantum dots.
Case study dog
|Improvement:||16 of 21 cases (76 %)|
|Equal:||2 of 21 cases (10 %)
1st case tumour patient difficult to assess
2nd cases: Simultaneously treatment with Hyalovet. Eventually side effects
|Worsening:||3 of 21 cases (14 %)
1st case recidive of synovialitis
2nd case autoimmune polyarthritis
3rd case: Simultaneously severe neurological problem